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Exercise caution or seek alternatives in patients with prior anaphylaxis to parenteral vitamins

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[12] mhra.gov.uk

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The researchers assessed the hepatic capacity for synthesizing urea-N (CUNS), which is a potential indicator of nitrogen metabolism in the liver

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Cyanocobalamin works but requires more metabolic conversion and releases trace cyanide (clinically insignificant at normal doses, but unnecessary when better forms exist)

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Future medicinal chemistry efforts may yield next-generation compounds with enhanced properties, including improved tissue selectivity, modified pharmacokinetics, or additional mechanistic activities that complement NNMT inhibition

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